免疫调节蛋白AIRE抗体

简要描述：免疫调节蛋白AIRE抗体免疫原；KLH conjugated synthetic peptide derived from human PGA1/AIRE: 51-150/545

产品型号：GOY-01K2337
厂商性质：科研
更新时间：2023-10-24 00:00:00
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详细介绍

免疫调节蛋白AIRE抗体

产品名称	英文名称	货号
免疫调节蛋白AIRE抗体	AIRE	GOY-01K2337

商品属性：

英文名称: AIRE

中文名:免疫调节蛋白AIRE抗体

别名；AIRE-1; AIRE; AIRE_HUMAN; AIRE1; APECED; APECED protein; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; Autoimmune regulator; Autoimmune regulator protein; PGA1.

研究领域；细胞生物免疫学信号转导转录调节因子锌指蛋白

抗体来源；Rabbit

克隆类型；Polyclonal

交叉反应；(predicted: Human, Mouse, Rat, Dog, Horse, )

产品应用；ELISA=1:5000-10000

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量；58kDa

细胞定位；细胞核细胞浆

性状；Liquid

浓度；1mg/ml

免疫原；KLH conjugated synthetic peptide derived from human PGA1/AIRE: 51-150/545

亚型；IgG

纯化方法；affinity purified by Protein A

缓冲液；0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

注意事项；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍:

The autoimmune regulator gene, which is defective in the hereditary auto-immune disease APECED, encodes the transcriptional activator AIRE. AIRE is expressed in the medullary epithelial cells and monocyte-dendritic cells of the thymus, with lower expression in the spleen, fetal liver and lymph nodes. In adult tissue, AIRE expression in the thymus is confined to the medulla and the cortico-medullary junction, where it is modulated by thymocytes undergoing negative selection. At the cellular level, AIRE is located in microtubular structures of the cyto-skeleton and in discrete nuclear dots resembling ND10 nuclear bodies. AIRE is induced by developing early thymocytes and is associated with the correct establishment of a regular thymic environment. AIRE regulates thymic architecture via transcriptional control of downstream target genes. AIRE mutations in APECED patients may affect thymic T cell selection and the formation of self-tolerance.

Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.

多克隆抗体制备：

完美体育平台合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。

鼠单克隆抗体制备:

客户可根据项目实际需求情况灵活选择进行，完美体育平台将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。

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重组抗体表达服务:

重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。完美体育平台已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。

单项免疫学及检测服务:

完美体育平台也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。

抗体定制服务:

已注册商标，主要用于抗体药物发现和开发，是完美体育平台针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。

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